Laboratory of Regulatory Genomics
Our research aims to decode the regulatory genome in aging and age-related diseases, driven by the principle that a comprehensive, system-level understanding of genome regulatory circuits is essential for uncovering the causal genetic and molecular mechanisms underlying human diseases.
In our research, we leverage cutting-edge sequencing technologies and advanced machine-learning models to unravel genetic and epigenetic regulatory networks. By integrating data from genome-wide association studies (GWAS), functional genomics, single-cell epigenomics, and molecular experiments, we focus on four key research areas:
>> Dissecting regulatory non-coding variants in human disease
>> Epigenetic regulation in aging and age-related disease
>> Identifying cellular origins of complex human disease
>> Mapping epigenetic dynamics in mammalian development
Research for Healthy Aging
Wellness at every age
Department of Biomedical Genetics & University of Rochester Aging Institute
Lab News
| 03/17/2025 | Welcome Zhicheng Jin, joining us for his rotation research. |
| 03/17/2025 | Welcome Jacqueline Morin, joining us for her rotation research. |
| 02/07/2025 | Hongbo's study is published in Science. This study integrated >30 types of genomic and epigenomic datasets and revealed convergent coding and regulatory variants in GWAS loci associated with kidney disease. |
| 02/03/2025 | Hongbo has joined the Impact of Genomic Variation on Function (IGVF) Consortium as an Affiliate Member. Working with IGVF, we develop computational approaches to explore how regulatory variants affect epigenetic regulatory networks and disrupt gene expression in complex diseases. |
| 01/06/2025 | Welcome Nidhi Shah, joining us for her rotation research. |
| 09/15/2024 | We receive a five-year research award from the National Institute on Aging. This award will support our collaborative efforts with scientists, including Professors Vera Gorbunova and Andrei Seluanov, to investigate the functional genome and epigenome related to longevity and Alzheimer's disease. |
| 08/16/2024 | Welcome Dr. Mengying Zhang (Postdoctoral Associate). Dr. Zhang brings extensive expertise in bioinformatics, epigenetics, and human diseases. Her current research focuses on the genetic and epigenetic basis of chronic diseases. |
| 03/01/2024 | Liu lab officially launches, with multiple Positions available. Welcome to join! :) |
| 01/01/2024 | Open postion: Postdoctoral Associate of Computational Biology. Visit Positions page for detail. |
| 01/01/2024 | Open postion: Postdoctoral Associate of Molecular Biology. Visit Positions page for detail. |
| 01/01/2024 | Open postion: Graduate students in PhD program: Biomedical Genetics and Genomics at University of Rochester. Rotation positions are available. |
| 01/01/2024 | The Liu Lab website (https://hbliulab.org) is now live! |